BTIG Analyst Raises Price Target for Spyre Therapeutics (NASDAQ:SYRE) to $112 Amid Positive Clinical Trial Results

Font: Financial Modeling Prep  • Jun 15, 2026

• BTIG has significantly raised its price target for Spyre Therapeutics to $112, indicating a potential 34% upside for investors.
• Spyre's experimental drug, SPY002, achieved its primary and secondary endpoints in a Phase 2 trial for inflammatory bowel disease, demonstrating significant efficacy and a favorable safety profile.
• The market responded positively, with Spyre's stock reaching a new yearly high and its market capitalization growing to approximately $5.05 billion.

An analyst from BTIG has increased the price target for Spyre Therapeutics (NASDAQ:SYRE) to $112. Spyre is a biotechnology company that develops treatments for inflammatory bowel disease. With the stock trading at $83.58, this new target suggests a potential increase of about 34% for investors, reflecting growing confidence in the company's future.

This optimism follows positive news about Spyre's experimental drug for bowel disease. As highlighted by Reuters, the drug successfully met its main objective in a mid-stage trial. The trial showed a significant reduction in the severity of the disease, which is a major step forward for the company and its potential treatment.

According to a GlobeNewswire release, the Phase 2 trial for the drug, SPY002, met its primary goal. It showed a 10.7-point reduction in a key disease measurement score after 12 weeks. The study also achieved other important goals, with 33% of patients reaching clinical remission and 42% showing endoscopic improvement.

The company also reports that SPY002 was well-tolerated by patients during the trial. Its safety profile was consistent with similar drugs in its class. Spyre delivered these Phase 2 results within one year of its Phase 1 data, showing strong operational speed as it moves toward more trial results this year.

The market has responded positively to these developments. Shares of Spyre are trading at $83.58, an increase of $2.79, or 3.45%, for the day. The stock reached a new yearly high of $84.69 during the session. The company now has a market capitalization, or total value, of approximately $5.05 billion.