Top Stock Market Losers: Sharp Declines Hit Several High-Volume Movers

Font: Financial Modeling Prep  • Sep 28, 2026

• ITG Inc (NASDAQ: ITG)., Adicet Bio, Inc. (NASDAQ: ACET), and Jaguar Health, Inc. (NASDAQ: JAGX) posted steep losses.
• Several declines followed recent positive updates, suggesting possible profit-taking or broader risk-off trading.
• High trading volumes point to active investor repositioning.

Today’s biggest decliners included ITG Inc., Adicet Bio, Inc. (NASDAQ: ACET), Jaguar Health, Inc. (NASDAQ: JAGX), Ocular Therapeutix, Inc. (NASDAQ: OCUL), and Greenland Mines Ltd. (ticker not provided).

ITG Inc (NASDAQ: ITG) fell 32.59% to $7.07 despite reported strong Q2 results. Adicet Bio, Inc. (NASDAQ: ACET) dropped 29.60%to $6.35 after positive Phase 1 data, suggesting investors may have taken profits after the announcement.

Jaguar Health, Inc. (NASDAQ: JAGX) declined 21.82% to $6.02, following a prior rally tied to a pipeline update. Ocular Therapeutix, Inc. (NASDAQ: OCUL) fell 20.67% to $7.66 on heavy volume, even as the company remained on track for an important FDA submission.

Greenland Mines Ltd (NASDAQ: GRML) dropped 19.17% to $11.85 despite expanding European investor access through a Frankfurt Stock Exchange listing.

In summary, the day’s top losers saw sharp pullbacks despite several positive company updates. The declines appear tied to profit-taking, volatility, and broader investor caution rather than a single shared negative catalyst.